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Mobile phases consisted of Solvent A (60% ACN, 40% HO, 10 mM Ammonium Formate with 0.1% Formic Acid) and Solvent B (90% IPA, 10% ACN, 10 mM Ammonium Formate with 0.1% Formic Acid)

After 4 weeks on the 0.25 mg, increase the dosage to 0.5 mg once weekly

doi: 10.1038/onc.2017.38

they are better interpreted as reassuring for cardiovascular safety when tirzepatide is used to treat coexisting obesity or diabetes in HFrEF rather than as evidence of HFspecific efficacy [49]

Observational studies have found that better vitamin C status is linked to protection against coronary artery disease, stroke, and high blood pressure