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Clinical Consequences of Delayed Gastric Emptying With GLP-1 Receptor Agonists and Tirz, Volume 110 Issue 1, De Block, C., Bailey, C., Wysham, C., Hemmingway, A., Allen, S

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These results represent the first demonstration of a cardiovascular outcomes benefit specifically in HFpEF patients and suggest the obesity phenotype of heart failure may be particularly responsive to metabolic therapy

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The safety profile of orforglipron looks promising, with side effects that were mostly mild to moderate and typical for the GLP-1 class (things like nausea, diarrhea, or constipation)

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