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A similar approach was successfully applied to develop selective drug activators of the protein kinase AMPK, which were revealed to bind to an unexpected allosteric site on AMPK that is distinct from the canonical AMP-binding sites [213,214,215,216]

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--- 4 Pharmacokinetics Parameter Detail Absorption Well absorbed orally Bioavailability ~100% Peak Plasma Time 34 hours Half-life ~70 hours (once daily dosing) Metabolism Liver (CYP2D6 & CYP3A4) Excretion Urine (major), feces Long half-life Once daily dosing

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