how does a glp 1 inhibitor work Mechanism of action of GLP-1 [25] How does sitagliptin work? DPP-4
Description
The NMPA released draft data exclusivity regulations in 2025 that, if finalized as proposed, would provide six years of data exclusivity for innovative small-molecule drugs and 12 years for biologics
![how does a glp 1 inhibitor work Mechanism of action of GLP-1 [25] How does sitagliptin work? DPP-4](https://i.ytimg.com/vi/FePjKBoFICA/hq720.jpg?sqp=-oaymwE7CK4FEIIDSFryq4qpAy0IARUAAAAAGAElAADIQj0AgKJD8AEB-AH-CYAC0AWKAgwIABABGHIgQyhDMA8=&rs=AOn4CLB3UAUjncQHc-L-xWLOGHwBykoE5g)
J Clin Invest 97:92103 Miholic J, rskov C, Holst JJ, Kotzerke J, Meyer HJ (1991) Emptying of the gastric substitute, glucagon-like peptide-1 (GLP-1), and reactive hypoglycemia after total gastrectomy
![how does a glp 1 inhibitor work Mechanism of action of GLP-1 [25] How does sitagliptin work? DPP-4](https://www.ijbs.com/v17/p2050/toc.jpg)
B_Tieup_ partnerships with biotechs (e.g., Gene tech) and AIdriven drug discovery
![how does a glp 1 inhibitor work Mechanism of action of GLP-1 [25] How does sitagliptin work? DPP-4](https://static.wixstatic.com/media/9185eb_20772a96806a4dd291c540ad345b6df7~mv2.png/v1/fill/w_850,h_667,al_c,q_90/9185eb_20772a96806a4dd291c540ad345b6df7~mv2.webp)
However, we often wonder, is this purely from weight loss and glucose control, or is there a more direct effect on the heart
![how does a glp 1 inhibitor work Mechanism of action of GLP-1 [25] How does sitagliptin work? DPP-4](https://www.frontiersin.org/files/Articles/1590530/xml-images/fcdhc-06-1590530-g002.webp)
In addition, these studies only included men, with no mention of kidney stone status, nor weight changes
![how does a glp 1 inhibitor work Mechanism of action of GLP-1 [25] How does sitagliptin work? DPP-4](https://www.apexanesthesia.com/wp-content/uploads/2024/05/article_GLP1_organ_effects.jpg)
These findings demonstrate two key outcomes
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