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After 3 months of treatment, exenatide high and low responders showed a decrease in the thermic effect of food (high responders 0.96 kcal/kg, p=0.04, low responders 1.55 kcal/kg, p=0.006, Table 2 )

Like I said, its FDA approved in my experience, weve not had a lot of success with it

Theres also the osteoporosis factor

Claude Bernard Lyon, Pierre Bnite, France

STEP TEENS: A Research Study on How Well Semaglutide Works in Adolescents With Overweight or Obesity

A patient carrying FTO rs9939609 variants, for example, may have heightened appetite-regulation challenges, but genetic testing clarifies whether that challenge requires additional medications or targeted behavioral and nutritional interventions