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Retatrutide, through its powerful GLP-1 and GIP agonism, dramatically improves insulin sensitivity and lowers circulating insulin levels

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Semaglutide (Ozempic ) 1 mg demonstrated superior and sustained weight loss of 6.5 kg compared with 3.0 kg with dulaglutide (another GLP-1 analogue)

In summary, GLP-1 receptor agonists regulate hepatic lipid metabolism in MASLD through activation of AMPK-mediated fatty acid -oxidation, suppressing lipogenesis-related gene expression, and enhancing lipid export and autophagy

Future research should be conducted to determine whether the renal benefit of different GLP-1RAs varies by patients underlying renal function