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It reduces peripheral insulin sensitivity by interfering with insulin receptor signaling, promoting hepatic gluconeogenesis, and increasing free fatty acid levels

Its main physiological roles include stimulating insulin release in a glucose-dependent manner, suppressing glucagon, slowing gastric emptying, and reducing appetite

In humans and rodents, GLP1 levels are reduced in obesity, while bariatric surgery dramatically increases postprandial levels of GLP1 (Chambers et al., 2014

[DOI] [PMC free article] [PubMed] [Google Scholar] 331.Li, H., Wang, D., Yuan, Y
