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GIP Agonism Effect in Diabetic Nephropathy The nephroprotective effect of tirzepatide has not been directly studied, however, the effect of GIP agonism on inflammation has been extensively documented (Figure 2)

Prime the pen (if using it for the first time) by turning the dial and pressing until you see a drop of medicine

doi:10.1038/s41586-026-10330-z Wharton S, et al

Sleep deprivation disrupts hunger hormones, increasing ghrelin and decreasing leptin, which undermine tirzepatide appetite suppression effects

While semaglutide targets one receptor, tirzepatide is a dual-action agonist

Each patient is evaluated individually to ensure safety and eligibility