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D., Wharton S., et al

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Both trials enrolled adults with a body mass index (BMI) of 30 kg/m or greater (or 27 kg/m with at least one weight-related comorbidity) and moderate-to-severe OSA (AHI 15 events per hour)

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Most patients begin at 0.25 mg once weekly, then progress by 0.25 mg increments every four weeks until reaching a therapeutic dose between 1.0 mg and 2.4 mg weekly
