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Importantly, although RETA-w/d restored the tumor transcriptome close to that of Veh, the tumor progression remained relatively blunted, which could be due to factors external to the tumor including systemic metabolic effects, such as insulin concentration, which were only partially restored after RETA-w/d, as discussed above

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May 20 2020;12(5)doi:10.3390/nu12051488 Valls RM, Pedret A, Calderon-Perez L, et al

The SURMOUNT-3 study raised some concerns regarding attrition bias due to missing outcome data