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Studies have shown that GLP-1 treatment significantly increases the expression levels of BTG2, Pdx1, and the insulin gene in pancreatic cells, indicating that GLP-1 positively regulates insulin gene expression through BTG2, thereby promoting insulin synthesis ( 4.2 Promotion of insulin secretion GLP-1 stimulates insulin secretion in a glucose-dependent manner through specific receptors expressed on pancreatic cells.GLP-1R is a family of secretins (class B) that couples GLP-1 to downstream cell responses, and conformational changes in the receptor upon ligand binding facilitate the interaction between its intracellular region and signaling proteins (Lamont et al., 2012)

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Mechanisms of action of GLP-1 in the pancreas

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