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Cardiovascular Effects Dose-dependent increases in heart rate were observed with retatrutide: Heart rate increases peaked at approximately 24 weeks Gradually declined thereafter while remaining elevated above baseline This pattern is similar to that observed with other GLP-1 receptor agonists[4] The clinical significance of these heart rate changes requires further evaluation in larger and longer-term studies

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In terms of switching, 22.9% of the GLP-1 receptor agonist users and 2.1% of the SGLT2 inhibitor users switched between drugs within the same drug class

A Wegovy bowel obstruction lawsuit indicates a woman suffered severe injuries and hospitalization, as well as stomach paralysis, after receiving injections of the weight loss medication.
