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provides microdosing GLP-1 under a monitored medical program to begin treatment, manage side effects, and achieve steady long-term improvements

Pierret ACS, Mizuno Y, Saunders P, Lim E, De Giorgi R, Howes OD, McCutcheon RA, McGowan B, Sen Gupta P, Smith D, Ismail K, Pillinger T (2025) Glucagon-Like Peptide 1 Receptor Agonists and Mental Health: A Systematic Review and Meta- Analysis

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When the research team analyzed individuals with a PAM variant called p.S539W, they expected to find lower GLP-1 levels