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showed in a recent retrospective study that GLP-1 RA use was not associated with an increased risk of pancreatic cancer [87]

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Whether this is a direct action of metformin on GLP-1 release, and whether some of the glucose-lowering effect of metformin occurs due to GLP-1 release, is unknown

Individuals with type 2 diabetes typically experience an impaired incretin effect, though GLP-1 secretion itself may be normal, slightly reduced, or context-dependent

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