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Two reviewers independently conducted the quality assessments, and any discrepancies were resolved through discussion or consultation with a third reviewer (A.N

Dipeptidyl peptidase IV-resistant [d-Ala2]Glucose-Dependent Insulinotropic Polypeptide (GIP) improves glucose tolerance in normal and obese diabetic rats

International Consensus Development International guidelines have shown similar evolution toward continuation with risk mitigation (Table 2)
In 2024, FDA issued a safety communication stating that their review did not find clear evidence of an increased risk of suicidal thoughts or actions with GLP-1 receptor agonists, but they continue to evaluate data

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Mechanistically, high-glucose conditions induced robust upregulation of BMP4 and increased phosphorylation of its downstream effectors Smad1/5/9, driving tumorigenic signaling
