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Mangano DT, Layug EL, Wallace A, Tateo I

Your provider might recommend temporarily pausing dose escalation, extending the interval between dose increases, or switching to an alternative formulation

Retatrutide data in diabetes populations is still emerging from the TRIUMPH trial program

all changes were transient and fully reversible

This article was originally published in the May 2025 issue of The Physiologist Magazine

In 1972, Svetlana Mojsov was a PhD student at Rockefeller University in New York City under the tutelage of biochemist Bruce Merrifield, who had developed a new, efficient way to produce peptides in a lab (for which he would win a Nobel Prize in 1984) called solid-phase peptide synthesis. For her doctoral thesis, Mojsov used this method to achieve something that had eluded researchers for decades: She successfully synthesized glucagon, a complex hormone the body produces to raise blood sugar levels when necessary, which was of particular interest to endocrinologists as a potential treatment for diabetes