glp 1 drugs adverse effects Do The Benefits of GLP-1 OutWeigh the Negatives? Clinical Recommendations to Manage Gastrointestinal

For patients with pre-existing mild or moderate DR, the effects of GLP-1 drugs could significantly worsen this condition

GIPR adipo/ mice showed significant reductions in interleukin-6 (IL-6) mRNA expression in adipocytes, blood IL-6 levels, triglyceride accumulation in the liver, and systemic insulin resistance [104]

Exercise and physical activity optimization Resistance training is non-negotiable during rapid weight loss

In a large phase 3 obesity trial (ACHIEVE-1), orforglipron at daily doses of 3, 12 and 36 mg caused approximately: Diarrhoea: 1926% of participants (vs 9% on placebo) Nausea: 1318% (vs 2% on placebo) Constipation: 817% (vs 4% on placebo) Vomiting: 514% (vs 1% on placebo) Across multiple studies, 617% of people stopped treatment because of side effects, mostly gut-related symptoms

[6] Okunogbe, A., Nugent, R., Spencer, G., Ralston, J., & Wilding, J

These improvements in healthcare infrastructure increase the availability and affordability of insulin and GLP-1 receptor agonists, hence supporting market expansion