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Broadly, studies suggest GLP-1RAs exert their neuroprotective effects in the retina by mediating reduced glutamate excitotoxicity, decreased neuroinflammation, prevention of retinal ganglion cell (RGC) loss, promotion of vascular integrity, promotion of an anti-oxidative environment, and maintenance of glial cells (i.e

Compounded medications are custom-made by a licensed pharmacy and can be a more affordable alternative to brand-name drugs

According to the FDA-approved prescribing information, injection site reactions occurred in 1.4% of Ozempic patients versus 0.6% in placebo groups

Microdosing tirzepatide has become a popular alternative approach, particularly for people who are sensitive to gastrointestinal side effects or who want to extend their medication supply

[1] [2] Renal and hepatic function may influence treatment outcomes

On Wednesday, the Food and Drug Administration issued a warning, calling compounded GLP-1 medications "risky for patients." "FDA is aware that some patients and health care professionals may look to unapproved versions of GLP-1 (glucagon-like peptide-1 (GLP-1) receptor agonists) drugs, including semaglutide and tirzepatide, as an option for weight loss," the FDA said