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Data on body weight and relevant clinical parameters were collected before and after 6 months of treatment with GLP1-RA

Weight loss on tirzepatide varies significantly between individuals due to metabolic, lifestyle, and genetic factors

What I'm watching: The Alzheimer's Association listed GLP-1 research as a top 10 development to watch in 2026

Retatrutide showed up to 28.3% weight loss in Phase 3 trials but is not yet FDA approved

Compared with SGLT-2 inhibitor use, GLP-1 receptor agonist use was not associated with an increased risk of pulmonary aspiration (pooled risk ratio 0.98, 95% CI 0.73 to 1.31), although it was associated with a higher risk for discontinuation of endoscopy (1.99, 1.56 to 2.53)

We talked to three doctors who prescribe GLP-1 medications to understand what its like to be on them the side effects that come when you start, the diet and exercise required while on them, and what it means to stop.