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Nonetheless, given its favorable safety profile and good tolerability, UDCA remains a useful therapeutic option in the early stage of MASLD, as early treatment of inflammation and apoptosis may help delay or prevent progression to advanced liver fibrosis, especially when used in combination with lifestyle modifications or agents with antifibrotic properties[65,77]

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Most of them, about 80%, were taking the GLP-1 for a diabetes indication, not for a weight management indication

Furthermore, VMH GLP-1R deletion did not significantly affect the anorexigenic effects of systemically administered exendin-4, suggesting that the VMH may not be a critical site for mediating GLP- 1RA driven appetite suppression [99]

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Ipamorelin eliminates these confounds, enabling clean attribution of all observed downstream biology to GH-specific mechanisms and serving as the essential selective control in comparative GH secretagogue study designs