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bolteae have been shown to directly promote proglucagon gene transcription and stimulate intestinal stem cell proliferation, effectively increasing the number of GLP-1secreting L cells

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Tirzepatide is also administered through a weekly injection

Glucagon-like peptide 1 receptor agonists (GLP-1RAs) demonstrate glucose-lowering, weight-reducing, and favourable anti-inflammatory and metabolic effects.1 These emerging drug classes have been proven to reduce cardiovascular events in patients with type 2 diabetes mellitus (T2DM) who are at high cardiovascular risk or have established cardiovascular disease.2 In this context, current guidelines recommend GLP-1RAs as first-line antidiabetic therapies in patients with established cardiovascular disease or high/very high cardiovascular risk.3 Semaglutide is a potent GLP-1RA used in the treatment of T2DM, with demonstrated cardiovascular benefits

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This program tests a small number of drugs in large, well-controlled, multi-center studies to see if they extend the lifespan of genetically heterogeneous mice