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Constipation With digestion slowed down and fibre often low (especially in the early days of reduced appetite), constipation is a frequent complaint

But the BBB tells a different story: an F rating for failing to respond to 9 out of 11 filed complaints

Potency Unknown

GLP-1 (glucagon-like peptide-1) medications mimic a natural hormone your body produces after eating

Well, weight loss patients have five chief complaints: Tolerability - GLP-1s can induce GI side-effects, like nausea and vomiting Durability - once GLP-1 therapy is discontinued, patients regain weight Frequency - most GLP-1s are administered sub-cutaneously every week Access - Medicare, Medicaid, and most commercial insurers dont cover GLP-1s for weight loss

This targeted distribution may help to understand the drugs action in the brain