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As a result, patients tend to feel fuller for longer periods and consume fewer calories naturally

Although short- and medium-term studies suggest that tirzepatide is generally well-tolerated, its long-term safety profile remains incomplete

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The duration required to obtain the desired number of events can be estimated from previous CVOTs, and the number of probable events in the placebo and intervention arms can both be estimated while predicting the direction of the effect size (hazard ratio)