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Rodent studies showed thyroid C-cell tumours, but humans have far fewer GLP-1 receptors on thyroid cells than rodents

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Semaglutide on Long-Term Outcomes in Heart Failure Patients with co-existing chronic kidney disease: A US Cohort Propensity-Matched Study Saturday, May 3, 2025

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Additionally, those with severe kidney disease or unstable heart failure may require dose adjustment or closer monitoring, though semaglutide does not directly harm the kidneys

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