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However, subsequent human studies have demonstrated minimal or absent GLP-1 receptor expression in thyroid follicular cells and inconsistent detection in parafollicular C cells, raising doubt about the translational relevance of rodent models [49,50]

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Furthermore, there may be concerns related to the patients ability to obtain alternative drugs that meet FDA approval and align with established editorial guidelines for therapeutic use

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In March 2024, a scoping review of 15 clinical trials, six case reports and one retrospective cohort study, published in the Journal of the American Academy of Dermatology reported that dysaesthesia occurred in 6 of 334 participants (1.8%) taking semaglutide and not in any patients taking placebo