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In preclinical models, co-administration of bimagrumab or dual myostatin/activin A inhibitors with GLP-1R agonists preserves or increases muscle mass while enhancing fat loss, resulting in improved body composition and metabolic outcomes compared with GLP-1R agonist monotherapy [176]
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GLP-1 receptor agonists also effectively reduce HbA1c while preserving beta-cell function, promote weight loss and do not cause hypoglycemia, DeFronzo said
Neurosci Lett 2003
