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These drugs also activate GLP-1 receptors in the hypothalamus, which increases the release of anorexigenic peptides like pro-opiomelanocortin while reducing the release of orexigenic peptides like neuropeptide Y and agouti-related peptide
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1 to postulate how these influences mediate a change in sexual desire from baseline
The strongest evidence right now is in knee osteoarthritis (the STEP-9 trial) and rheumatoid arthritis (the UCLA cohort), with rapidly growing data in psoriatic arthritis and lupus
Nystrom T, Gutniak MK, Zhang Q, et al
Do not assume
