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Common Side Effects and Safety Considerations Gastrointestinal side effects are the most frequently reported adverse reactions with GLP-1 receptor agonists, affecting a substantial proportion of patients, particularly during treatment initiation

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The large-scale STEP clinical trials (Semaglutide Treatment Effect in People with Obesity), published in the New England Journal of Medicine and JAMA, did not report increased cold sensitivity as a significant adverse effect

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10.1016/B978-0-444-62619-6.00003-3 36 KreymannB.WilliamsG.GhateiM
