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Small substituents at the 4-position (e.g., chloro, fluoro, cyano) provided the greatest potency

Summary: Health vs Hype Many people exploring GLP-1 patches may be doing so out of frustration, stalled progress, or confusion about safe weight loss options

Published 2022

Another meta-analysis conducted on adolescents with overweight/obesity without T2D reported that GLP-1RAs had a better anti-obesity effect when compared to placebo or lifestyle modification (semaglutide is better than liraglutide and exenatide for weight control) [35]

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