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Although rare, associations with nonarteritic anterior ischemic optic neuropathy, pancreatitis, medullary thyroid carcinoma, and acute kidney injury (AKI) have been reported, primarily through pharmacovigilance and case-based evidence

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Heart failure with preserved ejection fraction (HFpEF) is the most common form of HF, especially among people with obesity

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Tolerability depends on individual biomarkers, genetic predispositions, dosing strategy, and baseline health status