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Int J Geriatr Psychiatry aprile

Quite similar results, although of lesser extent and for lesser outcomes, have been observed with GLP-1RA [29]

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This initiates a cascade that leads to the activation of protein kinase A (PKA), closing of potassium channels, depolarization, and release of calcium from the endoplasmic reticulum.3 An increase of intracellular calcium levels within the cell initiates insulin expression in the nucleus, stimulates energy (ATP) production in the mitochondria, and triggers the release of insulin into the blood stream in a glucose dependent manner (image adapted from Adipogen Life Sciences).4,5 Several commercially and prescribed agents are now available for the management of obesity and type 2 diabetes

doi: 10.1900/RDS.2011.8.369

For changes in insulin level, although the result was not statistically significant, the effect size showed that GLP-1 receptor agonists could increase insulin content in vivo, which is consistent with the pharmacological effects of the drug