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66 (Tables 1 and 2) Current GLP-1RAs GLP-1RAs are synthetic protein preparations that have partial or complete amino acid sequence homology with GLP-1 found in the body, are not easily degraded, have longer half-lives and have stronger biological activity

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Discussion As the use of GLP-1 RAs continues to rise in the US for both diabetes and obesity management ( 1 , 2 ), understanding why patients discontinue these therapies is critical for improving long-term treatment outcomes

doi: 10.1038/s12276-018-0084-3 29 KangZ.ZengJ.ZhangT.LinS.GaoJ.JiangC.et al

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Lixisenatide as add-on to oral anti-diabetic therapy: an effective treatment for glycaemic control with body weight benefits in type 2 diabetes