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doi: 10.1016/j.ijbiomac.2017.03.177

Biochemical Pharmacology

It is FDA-approved for treating dry mouth caused by Sjogren syndrome and radiation therapy, and healthcare providers can prescribe it off-label for medication-induced xerostomia

Compared with the metformin plus sulfonylurea combination, the lowest risk for all three investigated endpoints, namely MACE, severe hypoglycemia, and all cause-mortality, was seen for people treated with metformin in combination with SGLT2is and GLP-1RAs (HR, 0.53 [95% CI, 0.350.80] for MACE

These usually happen when starting the medication or increasing the dose

Mechanism : Orforglipron activates GLP-1 receptors to reduce hunger, improve fullness, and slow stomach emptying