retatrutide glp-1 gip glucagon triple agonist mechanism GLP-1-based therapies for type 2 diabetes: from single, dual and triple agonists to endogenous GLP-1 production and L-cell differentiation Why target one pathway when

Diabetologia 36 (8), 741744

Acute Kidney Injury Due to Volume Depletion Inform patients of the potential risk of acute kidney injury due to dehydration associated with gastrointestinal adverse reactions

Bone 56:337342 Mieczkowska A, Mansur S, Bouvard B, Flatt PR, Thorens B, Irwin N, Chappard D, Mabilleau G (2015) Double incretin receptor knock-out (DIRKO) mice present with alterations of trabecular and cortical micromorphology and bone strength

It is a systemic inflammatory condition

however, GLP-1 receptor agonists and SGLT2 inhibitors are more strongly recommended over DPP-4 inhibitors

Several uncertainties remain