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Conclusions Across preclinical and translational studies, GLP-1RAs have emerged as promising candidates for NDD therapy, consistently modulating convergent mechanisms of pathology: IR, mitochondrial dysfunction, oxidative stress, proteostasis failure, synaptic loss, and neuroinflammation

2b, Supplementary Fig

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Kannt A, Madsen AN, Kammermeier C et al (2020) Incretin combination therapy for the treatment of non-alcoholic steatohepatitis

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These precedents highlight the need for indication-specific risk assessment and careful differentiation between mechanism-based toxicity and species-specific artifacts
