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Peripheral mechanisms appear to account for many of tirzepatide's metabolic effects

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This trifecta approach represents a leap forward in understanding how multiple hormonal signals can be harmonized to treat complex metabolic dysfunction

But one hormone is rarely part of the conversation: progesterone

Increasing attention has been directed toward the concept of a therapeutic window of opportunity, which frames early PsA as a transitional phase characterized by musculoskeletal symptoms such as arthralgia, dactylitis, and subclinical enthesitis in patients with PsO, often preceding clinically evident arthritis (12)
