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Resmetirom, the first FDA-approved drug for MASH: from drug discovery and action mechanisms to clinical trials

Additional receptor destinations involve retrograde transport towards the Golgi apparatus ( Evidence from primary mouse islets and clonal beta cells (INS-1 832/3) shows that Exenatide causes a greater amount of GLP-1R degradation compared to endogenous GLP-1, with this effect apparently due to differences in the susceptibility of the agonists for degradation by the endopeptidase endothelin converting enzyme 1 (ECE1) (Metzler et al., 2001) is associated with the control of GLP-1R function
8 studies and their data were extracted based on the protocol

They were assigned 10 or 15 mg of tirzepatide or placebo for 52 weeks

Collins L
