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However, these results should be interpreted considering the studys limitations, including its retrospective design, the absence of a control group, and the potential for selection bias

Novo Nordisk (Present Leader - Semaglutide Portfolio) CagriSema Mechanism: GLP-1 + Amylin agonist Stage: Phase 3 Expected filing: 2026 Weight loss: ~22-23% in trials Amycretin Mechanism: GLP-1 + Amylin Route: injectable + oral research Stage: Phase 2 Next-gen Oral GLP-1 programs Partnership with biotech firms to develop new oral obesity drugs 2

Notably, kidney-protective effects and reductions in UACR were observed regardless of concomitant SGLT2 inhibitor use [72]

17 (2020): 6275, 10.3390/ijms21176275

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