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Furthermore, the number of neuron-derived orphan receptor 1 (NOR1) which can modulate VSMC proliferation, is decreased by GLP-1RAs in a dose-dependent manner in mice [121]

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However, disruption of this pathway, particularly due to insulin resistance, can lead to impaired glucose utilization, oxidative stress, reduced GABA levels, and increased neuronal excitability, which ultimately contributes to seizure susceptibility and epileptogenesis [Table 3]

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