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Report any signs of bleeding (nosebleeds, gum bleeding, black/tarry stools, red/brown urine, easy bruising)

Summary Individualized therapeutic interventions should be crafted based on a comprehensive assessment, considering nutritional status, physical health, and the severity of liver disease
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Recent evidence from the STEP-HFpEF and STEP-HFpEF-DM trials provides the first robust data supporting the efficacy of GLP-1 RAs, specifically semaglutide, in improving the quality of life in obese patients with HFpEF

systematic review and meta-analysis
