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Unrealised Expectations Despite progress, several anticipated 2025 milestones did not come to fruition: Regulatory progress stalled: FDAs obesity drug guidance, published in draft form in January 2025, remains unfinalised, whilst EMA has yet to update its 2016 guideline

If EMA approval lands in 2H 2026 and supply scales smoothly, Novo could solidify leadership in the fastest-growing segment of metabolic medicine

Discover how injection timing impacts side effects, appetite suppression, and long-term weight loss success

The risk of heat-related illness may be higher among people taking GLP-1 medications like Ozempic, Wegovy, or Mounjaro

Individualize escalation (e.g., 0.75 mg instead of jumping from 0.5 mg to 1.0 mg) when appropriate

The second study analyzed the effect of a monoclonal antibody that inhibits muscle mass loss, but found limited benefit