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Glucagon-like peptide-1 (GLP-1) receptor agonists and dual GLP-1/glucose-dependent insulinotropic polypeptide (GIP) agonists, such as tirzepatide, have transformed the management of type 2 diabetes and obesity through durable glycemic control, weight reduction, and cardiovascular protection

Glucagon-like peptide-1 (GLP-1) receptor agonists were touted as breakthrough drugsin 2023 and their popularity has soared since. More than 4 million items of tirzepatide and semaglutide were dispensed on the NHS in England in 2025/20261, while around2.5 million people each monthaccessed GLP-1s privately at the end of 2025, according to James Kingsland, chair of []

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