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These results prompted the hypothesis on a direct role of GLP-1 in controlling pubertal development through the hypothalamic GnRH secretion, although this mechanism still remains to be unraveled

doi: 10.1016/j.brainres.2018.04.031 207 WilkinsonM

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In the phase 2 trial, 41% to 63% of participants receiving cagrilintide (0.3 to 4.5 mg) experienced gastrointestinal adverse events, compared to 32% with placebo