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Early-phase clinical trial data, including results from a Phase 2 trial published in The New England Journal of Medicine in 2023, demonstrated substantial weight reductions in some participants exceeding 20% of body weight over 48 weeks alongside a broadly manageable short-term adverse effect profile

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Address correspondence to: Danny Ben-Zvi, The Hebrew University of Jerusalem, Ein Kerem Campus, room 3038, Jerusalem 91120, Israel

Additionally, impaired leptin regulation in the liver disrupts satiety signals, driving overeating and creating a vicious cycle

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Effects of coffee polyphenol extract on active GLP-1(736) amide release in vivo CPE-administered mice had higher active GLP-1 levels in the portal blood at 10 and 30 min than those in the control mice (Fig