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GLP-1 stands for glucagon-like peptide-1, a hormone your body naturally produces in the gut after you eat

Benchmarking against SUSTAIN-6 and SURPASS-CVOT In the emulation of SUSTAIN-6 comparing semaglutide to sitagliptin, a proxy for placebo, in patients at moderate and high cardiovascular risk (Table 2 and Supplementary Table 19), the hazard ratio (HR) for the primary endpoint was 0.68 (95% confidence interval (CI) 0.600.77) compared to the trial estimate of HR 0.74 (95% CI 0.58 to 0.95)

By attenuating the subjective effects and reinforcing effects of alcohol, as supported by the present data and previous work, respectively (Egecioglu et al

Pain varies by individual

If you experience side effects, report them through the MHRA Yellow Card scheme

The delayed gastric emptying caused by GLP-1 agonists might compound existing digestive changes, though this interaction has not been systematically studied in large populations