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Both SUSTAIN-6 and LEADER showed a statistically significant decrease in MACE [53, 54]
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Gq activates phospholipase C (PLC), leading to hydrolysis of phosphoinositol diphosphate (PIP2) into products like IP3 and DAG, resulting in elevated Ca levels
Patients taking Qsymia showed an average weight loss of 8% to 10% after 56 weeks (or 13 months)
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But microdosing GLP-1s is not an established dementia-prevention strategy
