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Research Evidence Comparison# Retatrutide Research# The pivotal Phase 2 trial (Jastreboff et al., NEJM 2023) enrolled 338 adults with obesity and demonstrated weight reductions of up to 24.2% at 48 weeks

& De Fabritiis, G

Importantly, both dietary interventions negatively affected bone mass and mechanical strength

Ryan et al., 2020) and Verrucomicrobia (Gao et al., 2018
