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This effect has been observed both in vitro and in vivo

[DOI] [PubMed] [Google Scholar] 62.Statins: mechanism of action and effects

However, it remains uncertain whether the doses used for diabetes management achieve sufficient central nervous system penetration to produce clinically meaningful neuroprotective effects

It is well known that GLP-1 (7-36) (and GLP-1 [7-37]) is a primary insulinotropic hormone on the -cell mediated by the G-protein coupled receptor, GLP-1R, which activates cAMP-dependent PKA and PI3 kinase-dependent Akt signal pathways

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If you are starting fresh and have access to both medications, tirzepatide is the stronger first choice for the majority of situations