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Still, the best outcomes in trials occurred when medication was paired with structured routines, regular logging, and clinician-guided titration to preserve lean mass and manage side effects

People taking 9mg lost an average of 25.9% , while those taking 4mg lost an average of 19.0%

Many patients benefit from combining hormone replacement therapy with targeted peptide protocols

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Treatment must be prescribed through specialist NHS weight management services as part of a multicomponent programme including dietary and behavioural support