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While Ozempic effectively manages blood sugar levels in type 2 diabetes, its mechanism of action, which involves slowing gastric emptying as part of its glucose-lowering effect, could lead to patients developing gastroparesis

Finally, there is still not enough information to conclude whether GLP-1 drugs protect against the development of wet AMD

Further, active forms of GLP-1, as well as inactive metabolites, are rapidly eliminated by the kidneys ( The short half-life of endogenous GLP-1 has led to the development of GLP-1 receptor agonists (GLP-1RAs) and DPP-4 inhibitors as therapeutic strategies to extend the duration of GLP-1 action in the treatment of type 2 diabetes ( GLP-1 receptor agonists The first approved GLP-1 receptor agonist (GLP-1 RA) was exenatide in the United States of America (USA) in 2005 and in Europe one year later

Diabetes Metab Res Rev 2005;21:314 [DOI] [PubMed] [Google Scholar] 44.Schernthaner G, Currie CJ, Schernthaner G-H

Nausea is the most common side effect and up to 20% of people taking it for Type 2 diabetes reported nausea in clinical trials, according to GoodRx Health

Combination approaches pairing GLP-1 drugs with myostatin inhibitors (to preserve muscle) or with other metabolic targets are being explored